The textile industries utilize number of dyes, chemicals, and other materials to suffuse the characteristic of fabric qualities. A huge quantity of effluents is produced during the process. However, toxicity from synthetic dyes has become a cause of severe environment concern. Chlorophenols are mostly present in synthetic dyes which are proven carcinogenic and therefore undesirable. A number of techniques were used to remove p-Chlorophenol up to the ZDHC MRSL limit. However, none of them found to be up to mark. Fanton oxidation process was selected for its suitability to degrade the p-chlorophenol up to 5 ppm or less from the textile wet processing industry effluent. In the present study cotton fiber was selected, as medium considering its common use in textile industry. The impact of Ferrous ion (Fe+2), Hydrogen peroxide (H2O2) and pH on the removal of p-chlorophenol was examined. The Box-Behnken Design (BBD) of (RSM) was employed to achieve optimum desirable condition for the removal of pcp) from effluent. A quadratic model is suggested to relate the independent variables for maximum removal of p-Chlorophenol at the optimal process condition. Results suggest that removal efficiency under the optimum condition [Fe+2] = 6.5 x 10-3 M, [H2O2] = 2.9 x 10 -2 M, and [pH] = 3.5 was >90 % in 15 minutes. It can be summarized that Fenton oxidation process as the promising potential for removal of p-Chlorophenol from textile wet processing industry effluent. This research work helps to address for the general knowledge gap in the textile wet processing industry effluent treatment and provide a plate form for further research.