The Mio-plio-quaternary aquifer of the Djelfa Syncline is part of a region in Algeria which is characterized by the lack of surface water resources and located in a semi-arid climate. Since alluvial aquifers, and among them our aquifer, are the most vulnerable because of thier direct exposure to the pollution caused by the infiltrated pollutants, this work focused on the assessemnt of groundwater pollution vulnerability, hazard and risk. Thus, several methods were used, for this purpose, such as the DRASTIC and WQI methods mapped using a GIS. The results obtained clearly show a low to moderate vulnerability. The DRASTIC model and its validation based on the correlation with WQI revealed a low correlation (WQI vs DI : 0.221). Since the vulnerability model does not match with the groundwater quality, pollution risk was assessed by combining vulnerabilty and hazard (i.e, water quality). The risk map illustrated three levels ranging from low to high risk. This map should be helpful in decision making and groundwater management through avoiding high risk areas.