This work is devoted to study the effect of thermal conditions and concentrations on the diffusion permeability of a cation exchange membrane (MK-40) using sodium chloride (NaCl), sodium acetate (C2H3NaO2) and acetic acid (CH3COOH) solutions, which are usually highly concentrated components of pigment yellow 13 of industrial wastewater. A cell containing two compartments was used to analyze the properties of membrane. The results showed that the maximum diffusion permeability coefficients for NaCl, C2H3NaO2, and CH3COOH were 6.08×10-9 (m2/s), 13.29×10-11(m2/s), and 25.95×10-11, respectively. The increase in the CH3COOH solution concentration was found to improve the diffusion permeability. However, the NaCl and C2H3NaO2 solutions exhibited decreases in diffusion permeability with solution concentration. There was a significant increase in diffusion permeability with temperature.