In this study, the existence of long-term trends in ecological footprint (EF), biocapacity, GDP, population and CO2 emissions for the period of 1961-2016, and their effect on the demographic, economic and biocapacity indicators on Ecuador's EF were identified. The long-term trend analysis was performed by means of a Mann-Kendall, non-parametric test. The development of a multiple linear regression model of the EF considers the population, GDP, biocapacity and its logarithmic transformations as returners. A backward removal method was used, in conjunction with the Akaike criterion (AIC) to validate the most suitable model in terms of adjusted-R2, NSE, BIAS and RMSE, respectively. The results show significant changes (p<0.01) of the annual EF increase (0.015 hag), total population (216.375 inhabitants), GDP ($1.2 billion) and CO2 emissions (718.6 kt). However, the biocapacity has been declining (0.086 hag) at a faster rate than the ecological footprint. In other words, in a few years, the country will be facing ecological deficits. As for the empirical model of EF, it can be observed that for every increase of inhabitant’s units, the natural logarithm of biocapacity and GDP will increase EF by 1.68x10-7, 4.84 and 0.905 gha, respectively. Moreover, EF will be decreased by 0.6 gha each time the biocapacity increases by one gha unit. Finally, this robust and easy-to-interpret model allows accurate EF predictions that can be a tool to better forecast the environmental trends, allowing the development of sustainable projects in Ecuador.