This paper deals with estimation of methane emissions from the Mirash municipal solid waste sanitary landfill. Methane emission was calculated according to two different methodologies, namely, IPCC 2006 and LandGEM. Within the framework of the research, the following parameters were evaluated: amount of landfilled waste, landfill characteristics, and composition of landfilled waste and climate conditions prevailing in the region. According to the IPCC methodology, the total amount of methane emitted from the Mirash landfill during the period 2006–2017 was 30.57 Giga grams (Gg), while according to the LandGEM methodology, the total amount of methane emitted from the Mirash landfill in the period 2006–2017 was 26.32 Giga grams (Gg). The total mass of CH4 in the Mirash regional landfill for the years 2018-2025 is projected to be 53.74 Gg according to the IPCC method, while according to LandGEM method, the projection points to 50.74 Gg. This study was carried out for the sanitary landfill for solid waste management in Mirash, Prishtina Region, in the Republic of Kosovo, during the year of 2018.