This review examines the economic impact of Latin American regulations, strategies, and community involvement in mitigating the detrimental effects of mismanaged municipal domestic wastewater on public health, safety, and the economy. A systematic review and meta-analysis are conducted to assess the economic potential of reclaimed water in the region, utilizing various data sources and methodologies. The findings reveal that Latin America faces challenges in wastewater treatment, regulation, and resource management, affecting the market potential of reclaimed water. However, resource recovery initiatives present economic opportunities, including cost reduction, agricultural growth, energy recovery, and resource reuse.The study also highlights the lack of sanitation and wastewater treatment coverage data in many Latin American countries. By examining the commercial possibilities, regulatory frameworks, and environmental benefits of reclaimed water, this research provides valuable insights for sustainable water management and resource recovery policymakers, practitioners, and researchers. Furthermore, it emphasizes the economic advantages of utilizing reclaimed water and biosolids in Latin America, advocating for the implementation of strong regulations and policies to promote job creation and economic growth.