The objective of the work was to utilise multidimensional statistical methods to assess the physio-chemical status of waters of the River Liwiec catchment. Water quality assessment and comparison in terms of fifteen parameters were based on monitoring data collected at eight measurement points in 2017. Principal component analysis demonstrated that water quality in the River Liwiec catchment was principally conditioned by water temperature, pH, soluble oxygen content, nitrite nitrogen content and organic carbon content. Cluster analysis conducted based on principal components yielded three clusters of measurement points. The first cluster included the following measurement points: Liwiec-Kamieńczyk, Liwiec Wólka Proszewska, Liwiec Borzychy and Liwiec Krześlin. The waters at these points contained the least organic carbon and ammonium nitrogen. The second cluster consisted of the tributaries Muchawka Żytnia and Muchawka Rakowiec characterised by the highest amount of phosphorus, Kiejdhal nitrogen, ammonium nitrogen, nitrite nitrogen and organic carbon. The third cluster was made up of the tributaries Kostrzyń Proszew and Kostrzyń Łączka, both having the lowest values of nearly all the examined parameters.