This study goal to the ability of using low cost materials representing thermestone and aluminum solid wastes in water filtration by using a pilot plant constructed in wastewater treatment plant to remove cadmium II ion. Response Surface Methodology (RSM) used to optimize the optimal parameters that affecting the performance of filter units, these parameters are time, Cd (II) concentration, and filtration rate. These optimized parameters were 9 hr., 5 ppm, 10 l/hr. with removal efficiency of Cd (II) for A-Filter, T-Filter, S-Filter, and A-T-S-Filter was 94%, 95%, 86.8% and 90%, respectively. The result shows that the T-filter has higher cadmium removal efficiency than A-filter, S-filter and S-T-A- filter. While A-filter has a higher removal efficiency of cadmium than the S-filter and S-T-A- filter. While the S-T-A- filter has higher efficiency than S- filter. The result obtained from RSM was good Agreement with the result of experiments. As a result, the optimized process in this paper can be widely utilized with high removal ratio of Cd (II) ions from wastewater samples.