The paper analyzes the advanced technologies of wastewater treatment with a high content of organic pollutants and ammonium ions. Two different bi-stage scenarios for the treatment of such effluents are proposed. The first scenario includes the pretreatment in aerated lagoons and the final stage at the wastewater treatment plants after appropriate dilution with municipal sewages. The second scenario also includes the first stage in aerated lagoons with a tertiary treatment at the plant for cyanobacteria cultivation with the use of obtained biomass for biofuels production. The effects of the aeration periodicity on the leachate treatment efficiency and also on the composition of microbiocenosis in the aerated lagoons were investigated. Leachates of the Lviv landfill of municipal solid waste (MSW) were used in experimental investigations. Lviv landfill of MSW was used for domestic and industrial wastes deposition for almost six decades, since the 1960's. It was found that the highest effect of ammoniacal nitrogen removal was obtained in the mode of periodic aeration, with the cycle duration of two hours including the one-hour aeration. It is found that microorganisms extracted from the leachates of the Lviv MSW landfill are prospective for the new biotechnologies of treatment of the highly concentrated wastewaters, since this microbiocenosis is resistant to the widespread pollutants, in particular to heavy metal ions.