Bisphenol A (BPA) is widely used in everyday life and can be found everywhere, including in the ecosystem and manufactured goods. BPA not only has a negative impact in low doses, but it also has biological and pathophysiological implications for obesity and hormonal effects. The objectives of this paper were to review the BPA removal technology and the factors that influence the BPA removal based on biological methods. BPA elimination from water is crucial for environmental protection, in terms of biological treatment. In addition, the future prospect of biological removal of BPA indicates that effective microorganism cultures could disturb the pathogen growth and increase composition rate of BPA. The biological technology by the implementation of microorganisms for the removal of BPA through break down of organic contaminants is straightforward, money saving, and widely acknowledged by the public.