The Cisadane River, Tangerang City, is one of the most important rivers in Indonesia. This river provides raw water for Municipal Waterworks (PDAM) of the Tangerang City and Soekarno-Hatta International Airport, but the water quality tends to deteriorate due to pollution. The government has made various efforts to manage the river water quality, but no significant resolution was issued yet. The problem is becoming more complicated due to land-use changes that affect the pollutant load. Therefore, more precise, integrated, and comprehensive management is needed. This study used an approach with various methodologies according to the stages of the research, including; qualitative and quantitative analysis, GIS, statistics, risk management, and System Dynamic. The outcome of this research was the development of the policies in river water quality management, specifically land use management, separation of drainage channels from domestic sewage channels, enhancement of Wastewater Treatment Plant (WWTP) services coverage, as well as reinforcement of institutional and regulatory aspects, especially in funding commitments.