The dynamics of hydrochemical parameters of surface waters of the upper, middle and lower reaches of the river is analyzed. Based on the analysis of temporal and spatial monitoring data, a comprehensive assessment of the environmental status of the waters of the Inhulets river (Ukraine) by hydrochemical indicators was carried out. The study performed a comparative analysis of river water quality assessment by different methods: an integrated assessment based on the calculation of water pollution indexes, pollution rate. A result of the evaluation of water quality in certain classes: in terms of ammonium ions and BOD5 ˗ III quality class, the water is slightly polluted; phosphate content ˗ V quality class, water is very low in the bottom; according to the content of suspended solids, in phosphates and BOD5 ˗ III class of water quality, water is polluted; by a concentration of chlorides ˗ V class of quality, degree of purity ÷ very dirty; the value of suspended solids and chlorides ˗ III class; in terms of sulfate content ˗ IV class. In general, the very excessive concentration of substances in the middle course remains stable, the environmental state is poor (quality class IV).