Drip-based nanobubble fertigation technology (DNFT) represents a promising advancement in sustainable horticulture, particularly in the cultivation of high-value cash-crop vegetables such as chili, tomato, onion, and paprika, aiming to enhance nutrient availability, water use efficiency, and crop productivity. This research aims to comprehensively explore and assess the potential of DNFT in enhancing the sustainability of horticultural crop production. A systematic literature review and bibliometric analysis, conducted following the PRISMA framework and using Scopus and ScienceDirect search engines, resulted in 303 articles, of which 20 were deemed eligible for further review. The analysis results revealed a significant increase in DNFT-related publications over the past ten years. DNFT improves nutrient availability, microbial activity, and soil biochemical processes, boosting cash crop vegetable productivity (119%) and quality. These findings conclude that DNFT provides significant economic benefits, including water and fertilizer savings. However, challenges remain, such as the lack of comprehensive economic analysis covering costs and long-term viability across diverse farming systems. Future advancements may revolutionize vegetable production systems by enhancing yields while conserving vital resources such as water and fertilizers.