The reuse of wastewater from the combined wastewater effluents of the soy sauce, bread, and sticker peeling industries presents significant challenges due to high organic content and various pollutants. The highest problem is the very high organic content, which is the black organic color of soy sauce that causes a very high total dissolved solids (TDS) (809 mg/L) exceeding the total suspended solid (TSS) (320 mg/L). In addition, BOD5, COD, total phosphate, color, and total nitrogen are high (2415.08 mg/L; 3019.23 mg/L; 21.79 mg/L, 1477 PtCo, and 458.1 mg/L). The purpose of this research is to analyze anoxic-aerobic biofilter technology, by comparing the effectiveness of biofilters plus pretreatment, namely septic tanks with no pre-treatment, the best effluent that meets the standards, followed by an ultrafiltration process, to recycle it into clean water. The research method used a pilot-scale anoxic-aerobic biofilter reactor with a total volume of 110 L of wastewater. The results showed that the optimal removal of pretreatment modification of septic tank plus biofilter, which can reduce organic content by 90%, this value is greater than without pretreatment, by 78%. The best growing medium is the serrated bioball which has a large surface so that bacteria are easily attached due to the serrations on the surface of the bioball, which is then processed with ultrafiltration, obtained processed water quality according to established standards.