Pharmaceutical wastewater treatment plants (WWTPs) are critical points for the removal of pharmaceutical residues, including antibiotics, from industrial effluents before discharge into the environment. This study evaluated the effluent quality from a pharmaceutical WWTP in Indonesia, focusing on both standard physicochemical parameters and antibiotic residue levels. The physicochemical properties, such as COD, BOD, TSS, and pH, were compared to Indonesian regulatory standards. At Company XX, the removal efficiencies were 82.15% for COD, 82.71% for BOD, and 66.27% for TSS. However, the final effluent exceeded the discharge limits for COD and BOD by 22.74 and 2.38 times, respectively. In contrast, Company YY achieved a higher COD removal efficiency of 85.41%. The analysis of antibiotic residues focused on oxytetracycline (OTC), ciprofloxacin (CIP), amoxicillin (AMX), doxycycline (DOX), and cefadroxil (CEF). The results showed significant concentrations of OTC (3.887 mg/L in Company XX and 3.1473 mg/L in Company YY), CIP (2.849 m/L in Company XX and 1.711 mg/L in Company YY), and CEF (2.3871 mg/L in Company XX). AMX was detected at 2.1207 mg/L in Company XX. In contrast, AMX were below the LOD in Company YY. DOX was not detected in both company. The findings suggest that conventional treatment methods in pharmaceutical WWTPs are inadequate for eliminating antibiotic residues, underscoring the need for improved treatment technologies to mitigate antibiotic contamination and its ecological impact.