This study investigates the impact of nano pesticide formulations based on profenofos/polylactic acid nanofiber scaffolds. Using the coaxial electrospinning approach, nanofibers were obtained with an average diameter of 495.74 ± 86.46 nm. Release profile analysis revealed that approximately 32.6% of the active ingredient was released within the initial two weeks, increasing to around 82.15% after 15 weeks. The release pattern followed a non-Fickian behaviour, likely governed by both diffusion and swelling of the polylactic acid matrix. In field applications on maize, two scaffold-based formulations demonstrated prolonged protective effects, maintaining efficacy levels of 89.24 - 93.35%, compared with only 11.9% for the commercial pesticide Selecron 500EC after two weeks. These results demonstrate improved pest control performance of profenofos/polylactic acid nanofiber scaffolds. However, the experiment was based on an unreplicated field trial and did not include residue analysis, which limits the strength of the environmental interpretation. Therefore, the findings should be viewed as preliminary, and further studies are needed before drawing definitive conclusions about environmental benefits.