Bioplastic is a biodegradable material and environmentally friendly because it uses natural materials in the form of plant fibers. Plants with high fiber content can be converted to cellulose acetate as a raw material for bioplastics. Durian skin is a biomass waste that has the potential to be a raw material for bioplastics. Cellulose-based bioplastics are generally made by adding adhesives, plasticizers, and fillers. In this study, the manufacture of bioplastics used cellulose acetate from durian skin with variations of plasticizer concentration, plasticizer type, starch adhesive, and chitosan. Glycerol and sorbitol were used as plasticizers with variations in concentration of 20%, 30%, and 40%. The mass ratio of cellulose and starch used was 1.5: 1. Bioplastics was produced by adding chitosan, starch, and variations of plasticizers in each concentration which were achieved varying values in tensile strength, water absorption, density values, elongation values, young's modulus, degradability, and different bioplastic surface structures. The best bioplastic result is bioplastic with 20% sorbitol concentration for a density of 0.852 g/mL, water absorption of 45.99%, tensile strength of 613.12 Kpa, elongation of 2.35%, and young modulus of 26090.21 Kpa. In addition, the degradation time without landfill has met the Indonesian National Standard for 45 days.