The article is devoted to a comprehensive consideration of various options for the disinfection of sewage sludge. It is noted that the processes of sludge disinfection are still insufficiently studied, it is difficult to choose the appropriate treatment method in accordance with the physicochemical properties of the treated sludge and activated sludge. A comparative analysis of sludge compositions of different wastewater treatment plants is made. The authors determined the optimal conditions for the thermal treatment of sediments - temperature regimes and processing time, providing guaranteed disinfection of the material at minimal energy costs. The possibility of disinfection of a suspension of domestic sewage sludge using the cavitation-acoustic method is considered.