The aim was to study the impact of relief (slope, soil composition) and vineyard-related agricultural activities on groundwater contamination in the Rrezina area of Kosovo, a region with limited prior hydrological research. The research area is in Suhareka municipality, which has 40% of Kosovo's vineyards, making it a major grape-growing region. This vineyard area slopes directly towards the neighborhood and private wells. The water sampling and measurements procedure was followed in accordance with the standard methods for water examination according to EPA 2016. Physical parameters of the water were done during the sampling process. Results of the the chemical analyses of lead and iron concentration showed major contamination of the water of the wells. Lead values exceeded minimum values set by EPA and WHO in 19 of 20 wells, with an average value of 0.0358 mg/L. The concentration of iron was higher, and it exceeded the minimum values of EPA and WHO in all samples, with an average of 0.093 mg/L. Physical parameters of the water showed stable values of pH, conductivity, and temperature of the water; these values did not exceed EPA or WHO values. Microbiological parameters of total coliforms, E. coli and pseudomonas showed high fecal contamination of water, and all the wells exceeded the minimum value of WHO or EPA. Relief driven runoff from vineyards are primary contamination sources and there is high correlation (-0.81) between distance from the vineyards and lead concentration. This is the first integrated analysis of relief, agriculture, and multi-parameter contamination in Kosovo’s groundwater, even though the study is focused on 20 wells, which limits broader generalizations. The study highlights the need for periodic monitoring of wells near agricultural zones and improved wastewater management.