This study focuses on the influence of para-aminobenzoic acid (PABA) and ash on potato growing processes, with a special emphasis on the genetic potential of potato varieties to increase tuber stress resistance and improve nutrient assimilation efficiency. PABA, known for its properties in the biosynthesis of folic acid, is critical for cell division and growth of potatoes. Based on the data obtained, the effect of different concentrations of the acid on the physiological parameters of tubers, including their ability to withstand abiotic stresses such as drought and high temperatures, was analyzed and investigated. In addition, the issue of safe use of PABA in agronomy was considered, assessing its potential impact on environmental safety and sustainability of agrosystems. Black ash was also used to reduce the rate of mineral fertilizers. The research examined the benefits of using PABA in modern potato growing technologies, given the growing demands on the efficiency and environmental friendliness of agricultural products, which has become increasingly important in recent years in view of Ukraine's European integration. An important aspect of the use of biostimulants is a significant increase in the stress resistance of potatoes to adverse conditions, which has been a frequent phenomenon in recent years due to climate change on the planet. In the present study, in addition to the biostimulant, ash was used as a source of nutrients and trace elements, including phosphorus, potassium, and magnesium. Ash provided potatoes with starter nutrition during tuber germination, which additionally had an impact on the protection of planting material from diseases and pathogens. The use of biostimulants and ash can further reduce the cost of potato production for the farmer compared to expensive mineral fertilizers. In the study, it can be stated that the use of growth stimulants and ash has a positive effect on plant vegetation, stress resistance and potato quality compared to control combinations without the use of PABA.