Heavy metal salts, even in small quantities, accumulate in organisms, disrupt their cellular structures, and negatively affect growth and development processes. The situation requires in-depth research into methods and means that mitigate the effects of heavy metal salts on living organisms. In this study, the detoxification capabilities of the algae Eichhornia crassipes against the effects of cadmium and lead salts were evaluated using the example of Oryctolagus cuniculus. In experiments, biometric, physiological, and histological indicators in rabbits fed with Cd(CH3COO)2, Pb(C2H3O2)2 in the feed ration were stabilized as a result of the addition of dry biomass of E. crassipes. The primary data obtained on the detoxification properties of the algae E. crassipes for heavy metals are shown for the first time in the current study type, and the obtained data will serve to develop environmental recommendations for reducing the risk of Cd and Pb.