The research was carried out at the Instituto Superior Tecnológico "Luis Arboleda Martínez" (Jaramijó, Manabí, Ecuador), with the aim of evaluating the interactive effect of hybrid aquaculture using RAS-NFT technologies (Recirculating Aquaculture Systems – Nutrient Film Technique) on the physicochemical and biological parameters and productivity of Dormitator latifrons and Lactuca sativa var. Crisp. An aquaponic system of a 2000 L main reservoir, decanter, biofilter, degasifier, NFT modules and secondary reservoir was implemented, physicochemical and biological parameters of the water were monitored for five months at six points, applying the INEN 2176:2013 standard. The results showed the ability of the system to maintain water stability. The pH ranged from 7.63 to 8.19; total dissolved solids (TDS) ranged from 367 to 457 mg/L; electrical conductivity (EC) between 7.08 and 7.68 mS/cm; salinity was reduced from 4954 to 4580 ppm in NFT, then increased by evapotranspiration; and the temperature stabilized at 26.6 °C after dropping to 24.6 °C in the siphon. Dissolved oxygen (DO) decreased to 0.81 mg/L in the siphon, but recovered to 5.82 mg/L in the secondary reservoir. Alkalinity ranged from 44 to 60 mg/L, total hardness was reduced from 318 to 283 mg/L, chlorides from 91 to 79 mg/L, and turbidity remained stable except in the siphon (73.6 NTU). Total coliforms decreased from 137 to 73 CFU. The effect of the compartment (system components) by multivariate analysis (MANOVA) determined significance (p ≤ 0.001) on the physicochemical variables of the water. All multivariate statistics (Pillai Trace, Wilks Lambda, Hotelling Trace and Roy's Major Root) confirmed that the compartments of the aquaponic system are not homogeneous, indicating differences according to location. In terms of production, fish increased their biomass by 72.06%, while lettuce reached a weight of 940 g in the first harvest, while the second recorded 1081 g. Socially, community training achieved 87% attendance, with improvements of 30–35 percentage points in knowledge. The feasibility of integrating NFTs and RAS as sustainable production alternatives, optimizing water quality, biological efficiency and community participation, is demonstrated.