The wastewater treatment landscape in Central Europe, particularly in Poland, has undergone a profound transformation due to European Union (EU) integration. Fueled by EU funding and rapid technological advancements, wastewater treatment plants (WWTPs) have adopted cutting-edge control methods to adhere to EU Water Framework Directive mandates. WWTPs contend with complexities such as variable flow rates, temperature fluctuations, and evolving influent compositions, necessitating advanced control systems and precise sensors to ensure water quality, enhance energy efficiency, and reduce operational costs. Wastewater mathematical modeling provides operational flexibility, acting as a virtual testing ground for process enhancements and resource optimization. Real-time sensors play a crucial role in creating these models by continuously monitoring key parameters and supplying data to predictive models. These models empower real-time decision-making, resulting in minimized downtime and reduced expenses, thus promoting the sustainability and efficiency of WWTPs while aligning with resource recovery and environmental stewardship goals. The evolution of WWTPs in Central Europe is driven by a range of factors. To optimize WWTPs, a multi-criteria approach is presented, integrating simulation models with data mining methods, while taking into account parameter interactions. This approach strikes a balance between the volume of data collected and the complexity of statistical analysis, employing machine learning techniques to cut costs for process optimization. The future of WWTP control systems lies in "smart process control systems", which revolve around simulation models driven by real-time data, ultimately leading to optimal biochemical processes. In conclusion, Central Europe's wastewater treatment sector has wholeheartedly embraced advanced control methods and mathematical modeling to comply with EU regulations and advance sustainability objectives. Real-time monitoring and sophisticated modeling are instrumental in driving efficient, resource-conscious operations. Challenges remain in terms of data accessibility and cost-effective online monitoring, especially for smaller WWTPs.