This research examines the impacts of nano-calcium and zeolite treatments on germination and growth development in Zea mays. There were three experimental setups used, including germination in petri dishes, soil-based growth in germination trays, and combined application of nano-calcium as a load in zeolite within the soil. The first experiment reported a sharp decline in germination rate with increasing nano-calcium concentration, with the maximum germination rate reported at 0.5% concentration of nano-calcium (96%). There was also a sharp decrease in root length at increased nano-calcium concentrations. However, there were no effects on other growth parameters. The second experiment reported the positive role played by zeolite application, with a 2% concentration of zeolite significantly enhancing shoot growth compared to the control. There were no effects on other growth parameters. The third experiment illustrated that combined nano-calcium and zeolite application exerted significant effects on germination rates and biomass in plants with improved fresh and dry weight at moderate concentration levels of zeolite and nano-calcium. These results indicate that moderate levels of nano-calcium and zeolite have the potential to enhance plant growth by improving water retention and nutrient availability without causing toxicity.