Greenhouse cultivation, while offering year-round production, is often challenged by high temperatures and humidity, especially in arid and semi-arid regions. Traditional cooling and dehumidification techniques can be energy-intensive and environmentally unsustainable. This research explores a novel approach utilizing a high-salinity bittern solution as a desiccant to address these challenges. Bittern is a by-product of salt production. By leveraging the hygroscopic properties of salt solutions, this method offers a sustainable and energy-efficient alternative to conventional techniques. The proposed system aims to significantly reduce water consumption and minimize reliance on energy-intensive cooling technologies. A laboratory-scale dehumidifier column was employed to simulate both the dilution and regeneration processes of the desiccant. The performance of bittern was compared to a well-established desiccant lab grade CaCl₂. The results indicate the potential of the by-product brine water as a promising solution for sustainable greenhouse agriculture. The bittern solution has proven to be a viable and effective alternative to traditional chemical desiccants. The experimental data show that bittern performs comparably to CaCl₂ in terms of its ability to extract moisture from humid air under controlled conditions. This finding is significant because bittern solution is more readily available, cost-effective, and environmentally friendly compared to synthetic desiccants.