Most of the pollution levels of Lake Sentani waters in the Expo watershed (92%) have been mildly and moderately polluted, while only a small proportion (8%) still meet quality standards. The condition of the level of heavy pollution will be dangerous for the life of living things, especially fish and have an impact on humans. This study aims to analyze the priorities of the Sentani Lake pollution management policy in the Strength-Opportunity (SO), Strength-Threat (ST), Weakness-Opportunity (WO), and Weakness-Threat (WT) strategies with the A’WOT method. The results showed that the policy priorities that first needed to be implemented immediately in the SO strategy were to Improve Enforcement of Environmental Law with an eigen value of 0.196. The priority of the policy strategy that first needs to be immediately implemented in the WO strategy is to make regional regulations by utilizing Government and community support with an eigen value of 0.267. The first policy priority that needs to be immediately implemented in the ST strategy is to use government authority in the environment to control environmental pollution and damage with an eigenvalue of 0.494. The first policy priority needs to be immediately implemented in the WT strategy is to improve environmental law enforcement so that lake water is not polluted with an eigen value of 0.202.