Antibiotics are recognized as emerging environmental contaminants due to their persistence and adverse ecological impacts. Metronidazole (MMZ), a widely used nitroimidazole antibiotic, is of particular concern because of its extensive use and resistance to biodegradation. Its accumulation in the environment highlights the urgent need for effective removal strategies. The aim of current study was to synthesize economical iron oxide nanocomposite CI-NC catalyst from an indigenous sugar mill waste bagasse as source for cellulose via co-precipitation process for the sequestration of MMZ antibiotics from hospital waste water. CI-NC was characterized by energy-dispersive X-ray EDX, scanning electron microscopy (SEM), UV-visible spectroscopy and Fourier transform spectroscopy (FTIR). The hospitals wastewater was analyzed using HPLC for presence of MMZ. Experiments were designed by faced centered central composite design (FCCCD) in deign expert 13 and Response Surface Modeling (RSM) was employed for optimization of experimental variables used to analyze the main and interaction effects. The design variables were nanocomposite dose, pH, MNZ, temperature, hydrogen peroxide, and contact time. It was raveled that 98.00 % degradation achieved at composite dose of 10mg and MMZ 30 ppm, pH of 6, time of 30min, temperature of 313 K, H2O2 and 0.6mmol/L. A high degree of fit was achieved with the cubic model. The kinetic study revealed that the experimental data were best described by the pseudo-second-order kinetic model, with R² of 0.99. The present findings demonstrate the potential of cellulose iron oxide nanocomposite (CI-NC) as sustainable and efficient material for the sequestration of MMZ antibiotics form hospital waste and pharmaceutical industries.