Face Centered Cube Central Composite Design (FCCCCD) methodology was applied to optimize the Cr(VI) adsorption capacity of Arabica-coffee pulp biomass (WAC), qe, as a function of key-factors, such as pH, chromium concentration C0 and WAC-dose. The quadratic dependence of qe, with the considered factors, has shown a strong influence of pH. The optimal conditions found in this way were pH 2; C0 = 75 mg/L and WAC-dose= 0.5 g/L. The characterization of WAC, performed by FTIR and SEM/EDX, allowed the identification of OH, CH, CO, COH functional groups and also showed significant changes, particularly on WAC surface morphology, after biosorption. The experimental isotherm data (qe vs Ce) was well-fitted to three models: Langmuir, Freundlich and Temkin. Furthermore, thermodynamic and kinetic results showed that Cr(VI) biosorption using WAC is an endothermic and spontaneous reaction, following pseudo-2nd order kinetics. Finally, this work shows the feasibility of effectively using coffee biomass-waste, a low-cost material, for chromium removal in contaminated aqueous media.