This study aims to estimate the concentrations of air pollutants PM₁₀, NO₂, SO₂, and CO using Landsat 8 satellite imagery, validated with ground-based measurements at 41 monitoring points in the cement industry area of Pangkep Regency, South Sulawesi, Indonesia, and to evaluate air quality using ISPU indices. The methodology included radiometric and atmospheric correction of satellite imagery, extraction of spectral bands and land surface temperature, application of calibrated regression algorithms, comparison with ground-based measurements, and conversion of both satellite-derived and ground-based concentrations into ISPU indices to provide a comprehensive air quality assessment. The satellite-based estimations indicated PM₁₀ concentrations of 4.55–4.56 µg/m³, NO₂ of 23.59–72.15 µg/m³, SO₂ of 75.79–231.79 µg/m³, and CO of 83.3–83.6 µg/m³. Validation results showed that satellite-based estimates of NO₂ and SO₂ tended to be higher than ground-based measurements, whereas PM₁₀ and CO concentrations were lower than those measured in the field. Ground-based concentrations of the four pollutants, when converted into ISPU, ranged from Good to Moderate, while satellite-derived ISPU extended to the Unhealthy category. Despite these differences, the findings highlight the importance of integrating satellite imagery with ground-based observations to enhance air quality assessment, particularly in industrial regions with limited monitoring infrastructure.